With the increase in social competition, the improvement of living standards, and the influence of traditional Chinese thinking, many patients with liver disease have been neglected for regular check-ups. The current medical market chaos and the society’s bad perception of hospitals, “fear of being ripped off”, also caused some patients are not willing to go to the hospital for regular medical checkups; many patients lack medical knowledge, indifferent attitude, follow the “feeling”, or escape from the heart, simply cope with the matter. Some patients are afraid of disease, do not dare to face the reality, and there are many people who pretend to be confused; also includes some bad hospitals and doctors, based on the results of medical examinations, to intimidate patients and deceive families, is also an important reason why patients are not willing to go to the hospital, many reasons exist to cause patients are not willing to frequent medical examinations, resulting in family tragedies continue to occur. Here I will start with the basic principles of medicine and tell you the importance of regular testing for chronic diseases. 1. The research on liver disease is not deep enough, and the prediction of tumor development is unpredictable: Let’s start with an example: there was a patient with cirrhosis who had been treated with antiviral therapy for a long time, but the virus was always negative. This example shows that the research on the occurrence of liver cancer is not deep enough. Scientists cannot predict when liver cancer will occur, how it should occur and how to predict it? I often give patients the analogy: “Your corn field grows well, but there is no guarantee that weeds will not grow”. If weeds grow, it is not because of the problem of corn field, but because you did not find her. Since you cannot prevent it, what should you do? Look at the corn field more often and just dig it up when you find it. The same is true for the liver: although antiviral and antifibrotic treatment can greatly reduce the chances of liver cancer, it cannot be prevented or stopped from occurring and can only be detected by medical examination. According to the current scientific research, there is no drug or treatment that can prevent and interrupt the occurrence of tumor; at the same time, there is no rule for the regularity of tumor occurrence, therefore, regular testing is very important in this regard. 2. The limited means of tumor treatment and unreliability of efficacy also determine the importance of regular medical checkups: There are many local patients who come to my clinic with SCT or MRI films, hoping that the provincial experts will point out a way out for them. Indeed, the fear of life is the basic professional ethics that every doctor should have. However, for patients with advanced cirrhosis or hepatocellular carcinoma, doctors’ treatment means are limited. The only methods are surgery, chemotherapy and radiotherapy, but at present, the main means for liver cancer are only surgery (including surgical resection, transplantation, intervention and radiofrequency, etc.) and biological targeted therapy, the rest of the treatment is very limited, in fact, we all know that the current Chinese Sun Yat-sen, the modern Jiao Yulu and the famous actor Fu Biao, etc. are the reasons for this. However, this determines that the detection of tumor must be early, and only early detection is the main way to save patients. According to the basic principles of modern tumor treatment if the tumor is below 1-2cm in situ liver cancer, modern treatment methods can achieve more than 10 years of survival time; around 3-5cm, it can also live to more than 3-5 years; if it grows to more than 5cm, or multiple, metastasis, etc., it needs to go to Shaolin Temple to burn incense and worship Buddha. Therefore, only with regular review, doctors can find it early and solve it. 3. The rapidity and insidiousness of tumor disease development also determine the importance of regular physical examination: Liver tumor is different from other organ tumors in that the development is very rapid and the insidiousness is particularly strong. Although it takes 3-5 years for HCC to turn into tumor from sclerotic nodules (or even without nodules), it only takes about 6-9 months from the discovery of tumor to the end of life (if not treated), that is, the early detection of tumor within 1-5cm is especially important, that is, the discovery window period of 3-6 months is very critical, otherwise it will not give you time to think at all, so time is Therefore, time is life. In addition, many early tumors do not have any sensation, and there are no warning signs and phenomena in the body, so if you follow the sensation to discover the tumor, basically it is in advanced stage. What to do? Regular checkup is very crucial. 4, social factors and the accelerated pace of life, greatly promote the chance of tumor, also determine the importance of regular medical checkup: I do not want to say much in this, life is stressful, fast-paced life, smoking and drinking, stay up late common, irregular life, etc. body is always in a subhealthy state, in addition, the work environment is polluted, etc. are important factors to increase the tumor. In fact, hepatitis C virus and hepatitis B virus are key factors of carcinogenesis, for example, the core protein of HCV and the X protein of HBV are strong carcinogenic factors, which can activate oncogenes in the body and make tumor occur (so after antiviral treatment, the virus is turned negative and the chance of liver cancer is greatly reduced; however, the virus is not only in the body, but also in the body. However, when the virus is turned negative, it does not mean that the virus is cured, and a small amount of virus still exists, which is also an important factor for the occurrence of liver cancer). In addition, HBV, HCV, AIH, PBC, NASH and other causes can lead to the formation of cirrhosis, which is also a hotbed for the formation of HCC, mainly due to the continued progression of inflammation, maintenance of fibroblasts, hypoxia and immune factor chemotaxis, increased ROS response, resulting in RNA and DNA instability, coupled with the disruption of the intracellular and external environments, cell “natural selection”, genetic or genotypic targeted selection, and tumorigenesis. Therefore, tumorigenesis is also the result of natural selection, and therefore prevention and interruption are relatively difficult. 2. Which patients pay special attention to regular selection? 1. Which patients need special attention? There is no selectivity in disease occurrence, which is equal for everyone, but disease occurrence has certain tendency, which is related to the properties of the disease itself, social surroundings, genetic characteristics, and living habits. The occurrence of liver tumors or cirrhosis is mainly related to the following factors: 1. the number of viruses (many) and whether the virus mutates; 2. the duration of the disease (long), the length of time it takes for cirrhosis to form; 3. the severity of the disease, i.e. the degree of cirrhosis (high); 4. the combination of other diseases (diabetes, fatty liver, HIV, etc.) or the long-term use of other drugs (immunosuppressants, etc.); 5. age (older than 40 years), gender 5, age (older than 40 years), gender (male) and body mass index (BMI); 6, environmental factors (pollution) and lifestyle (alcohol consumption, etc.); 7, genetic factors (family history, etc.) and other factors are associated with the occurrence of HCC and the progression of cirrhosis. If you have the above factors should strengthen the medical examination. 2, regular testing absolute and relative: It is estimated that many patients see here, sucked back a breath of cold air. It’s too scary, but actually it’s not. Because hepatitis B, for example, all hepatitis B patients, the lifelong population does not need treatment accounted for more than 60%, while the emergence of cirrhosis or fibrosis accounted for 20-30%, this part of the need for treatment, while less than 1% of the people may appear HCC, so the problem is after all very few, so there is cirrhosis or HBV, HCV and other patients do not need to panic. Although the probability is low, it is not easy to accept for each individual, because it can lead to a broken family and children without support. No one can predict the trend of disease progression and development pattern, “strategically defy the enemy, but in tactics pay attention to the enemy”, for the current liver disease is a preventable and controllable disease, so should be regular long-term testing, mainly to observe the progress of disease in two groups of people, and take appropriate treatment measures after the problem is detected, so as not to let the disease develop to an uncontrollable state, and try to avoid social tragedy . Third, how to adhere to regular testing 1, regular testing is expensive? In fact, regular testing is not expensive, including liver function, ultrasound and AFP, all together cost less than 200 yuan, and is once every 3-4 months, an average of only about 40 yuan per month. Look at the cost of January is only equivalent to the price of 2 or 3 packs of cigarettes or 2-3 bottles of beer or a bag of cosmetics, smoking can lead to lung cancer, drinking can lead to cirrhosis of the liver, this can maintain health, why not? At the same time, regular testing can accurately provide doctors with changes in the condition, including the progression of cirrhosis, complications occur, which is extremely helpful in guiding treatment. 2, the basic content of regular testing: the actual just mentioned, mainly liver function, B ultrasound and AFP, the main purpose is to monitor the progress of cirrhosis and HCC, to provide appropriate treatment advice; if problems are found, you can further test the virus, SCT or MRI. 3, the hospital and doctors for regular testing: of course, the level of doctors and instruments is very critical, so it is very important to go to relatively regular hospital testing, in order to avoid missed diagnosis and misdiagnosis. To avoid missed diagnosis and misdiagnosis, including specialist hospitals, and finally never listen to advertising, there is no magic pill in the world. Fourth, regular testing considerations 1, according to the condition of the selection of appropriate regular testing content: such as healthy carriers, every 3-6 months to test liver function, ultrasound and AFP; if liver fibrosis, in addition to Fibroscan; if cirrhosis, should be added to the first half of a gastroscopy or MRI, SCT scan; if HCC post-operative, pay attention to SCT or MRI enhanced scan, plus AFP If you have gastrointestinal bleeding or postoperative, insist on gastroscopy and blood tests; if you are over 40 years old, especially if you have family history, you should check once every 3-4 months; if you are taking antiviral drugs for a long time, you should add HBVDNA; if you are using other immune agents in combination, you should add HBV-DNA. If you have a history of hepatic fibrosis or cirrhosis, you should have regular follow-up ultrasound and AFP; if you have AIH or PBC and other autoimmune patients, you should add immunoglobulin classification; if you have alcoholic liver or fatty liver, you should add Fibroscan, blood glucose, lipids, kidney function and blood pressure, etc. 2, before the test must be fasting: pay attention to relaxation, avoid excessive tension, avoid colds and diarrhea and other factors affect the test results, especially do not drink foods containing lipids or sugars, etc.. All of the above is to be noted. Conclusion: Although the medical examination is a bit of a waste of time, and the cost is particularly small, it is indeed very important, because things happen without regret. Therefore, for your well-being and that of your family, it is highly recommended that you form the habit of regular body testing, no matter how busy you are.