Major triple positive indicates that the patient is infected with hepatitis B virus and is highly contagious. If left untreated, the patient may develop cirrhosis and liver cancer, thus affecting life expectancy, a process that may take 10, 20 or 30 years, with large individualized differences. Major triple positive is positive for Hepatitis B surface antigen (HBsAg), Hepatitis B e antigen (HBeAg), and Hepatitis B core antibody (anti-HBC) among Hepatitis B five items. It may be chronic hepatitis B carrier or chronic hepatitis B. The former is in the immune tolerance period, mostly asymptomatic, and can be followed up regularly without medication; the latter is affected by age, immune status, alcoholism, viral replication level and other factors, and needs standardized treatment to improve the quality of life and prolong the survival time. Hepatitis B vaccination is the most effective way to prevent hepatitis B virus infection, and people with no contraindications should be actively vaccinated and regularly rechecked for antibodies. It is especially crucial for patients with triple III infection to have regular checkups, and to determine whether treatment is needed based on the tests.