Physiological jaundice in the neonatal period is self-limiting. If serum conjugated bilirubin exceeds 2 mg/dl, or if jaundice persists beyond the first 2 weeks of life, the infant should be observed for stool color at this time. If the infant’s stool color becomes pale, beige, off-white or even clay-like, it is a manifestation of cholestasis and associated diseases are: pharmacological, TORCH infections (toxoplasma, rubella, cytomegalovirus, hepatitis, etc.), genetic diseases (a-1 antitrypsin deficiency, Alagille syndrome, progressive familial intrahepatic cholestasis PFIC), metabolic diseases (e.g., cystic fibrosis Galactosemia), parenteral nutrition, and certain diseases called “neonatal hepatitis” that cannot be attributed to these diseases. Surgical disorders include: choledochal cysts, obstructive choledochal malformations, biliary thickening syndrome (common in premature infants), and spontaneous perforation of the biliary tract. Biliary atresia (BA) is a condition in which the intrahepatic or extrahepatic bile ducts are interrupted, slender, narrowed or atretic in the form of cords, and thus bile drainage is impaired, with clinical manifestations such as jaundice and light stool color. Early diagnosis and early surgery (around 60 days of age) are crucial factors to improve the survival rate of children with autologous liver. Minimally invasive laparoscopic cholangiography: Minimally invasive laparoscopic cholangiography can show the biliary structures inside and outside the liver in a simple, minimally invasive and reliable way. It can not only determine biliary atresia, biliary malformation, intrahepatic bile duct dysplasia (Alagille syndrome), pancreaticobiliary duct coarctation abnormalities, bile duct stones, biliary sludge; it is also feasible for bile stone extraction, bile duct irrigation and drug perfusion; it has definite therapeutic effect and obvious improvement effect on bile duct stones, biliary sludge, neonatal hepatitis and other refractory jaundice.