Aminotransferases of more than 300 U/L should be taken seriously and the cause must be investigated. If accompanied by other uncomfortable symptoms such as nausea, poor appetite, weakness and jaundice, the patient may need to be hospitalized for 10-15 days and the transaminases can mostly be reduced to normal. For patients with aminotransferases of more than 300 U/L, medications to lower aminotransferases, such as bupropion drops or dicyclomine tablets, can be taken as prescribed by the doctor if necessary. Usually after about 10-15 days of treatment, the patient’s transaminases can mostly be reduced to normal. For patients with underlying liver disease, such as viral hepatitis or other autoimmune hepatitis, if transaminases are elevated, further blood tests for hepatitis B DNA or hepatitis C RNA are required to observe whether the patient has viral replication, and if so, liver-protective therapy is required on top of active antiviral therapy. Liver-protective therapy can choose drugs such as reduced glutathione or diammonium glycyrrhizate, and the patient’s transaminases can gradually decrease to normal after about 10 days of active treatment. In addition, if the patient’s other test indicators are not abnormal and there are no other concomitant symptoms, regular rechecking after consultation is sufficient.