Ankylosing spondylitis occurs in young men in the prime of life. It certainly affects both young and old, and can occur in both men and women. The onset of spondylitis is insidious, with slow progression and a preferred prognosis. Those who develop spinal ankylosis, paralysis, or disability are the minority who are not treated in a timely manner, or whose disease progresses more rapidly. Most patients can get better results with the following options depending on their condition, and some patients may even observe significant structural repair of the sacroiliac joint. We hope that all patients with ankylosing spondylitis will be seen in a timely manner. Option 1: salazosulfapyridine + NSAIDs. The regimen used by most patients a decade or so ago. Affordable, well tolerated, and still suitable for patients with modest means. Option 2: total peony glucoside + salazosulfapyridine + NSAID. Option 3: leflunomide + salazosulfapyridine + NSAID. Option 4: leflunomide + total peony glucoside + salazosulfapyridine + NSAID. Options 2, 3, and 4 are all options that have emerged in the last decade or so, and are also affordable options for the general population, and are the golden options in my mind. Without rigorous observation and comparison of large samples, my personal experience is that the efficacy is better than that of regimen 1, regimens 2 and 3 have similar efficacy, and regimen 4 seems to be superior. All are suitable for patients with early and intermediate diagnosis. In some patients it can promote the repair of destructive lesions of the sacroiliac joint. In some patients with slightly advanced disease, thalidomide + NSAID can also be added to lufetilide. Regimen 5: (free combination of leflunomide, total peony glycosides and lufetilide) + biologic agents. A luxury formula for patients for whom the previous regimens are ineffective or less effective, but of course with one condition – family affluence.