Although there is no cure for ankylosing spondylitis (AS), the prognosis has improved considerably with the deepening of the understanding of the disease and the improvement of diagnosis and treatment. Treatment goals: 1. control inflammation and relieve symptoms; 2. prevent spinal joint deformities. Treatment methods: including two aspects, namely physical therapy and physical exercise and drug therapy. Physical therapy and exercise Physical therapy is the application of electricity, light, sound, magnetism, heat and other physical factors to treat the disease. Commonly used methods are, magnetic therapy, audio therapy, short wave and heat therapy. Physical therapy should be performed under the guidance of an experienced physical therapist. Exercise is very important for AS patients because it not only delays the progress of the disease, but also improves respiratory function, prevents muscle atrophy, maintains bone density and strength, and prevents osteoporosis. Therefore, AS patients should persistently exercise, do not be afraid of pain and take the method of moving less or even not moving. Medication Medication can control the patient’s symptoms faster, eliminate the inflammation, relieve the disease, and enable the patient to better exercise, but medication may bring various adverse reactions to the patient. Therefore, patients should understand the role of the drugs they take and the possible side effects, currently commonly used drugs for the treatment of AS are non-steroidal anti-inflammatory and analgesic drugs, chronic-acting drugs and glucocorticoids. 1.Non-steroidal anti-inflammatory and analgesic drugs: these drugs have fast onset of action and can control pain in a short time, so they are the most widely used drugs. Commonly used varieties are diclofenac sodium, euthyrox, ibuprofen, etc. Their common side effects are gastrointestinal adverse reactions. Patients with a history of peptic ulcers and bleeding should use these drugs with caution and combine them with gastric mucosal protectors when necessary. Recently marketed selective cyclooxygenase II inhibitors Mopiko and Emmerich have a higher safety profile for the digestive tract. 2, chronic-acting drugs: commonly used are salazosulfapyridine, methotrexate, etc.. These drugs have a slow onset of action and take about 3 months to take effect, so they are called slow-acting drugs. The side effects of these drugs are also more, in addition to gastrointestinal reactions, they also cause leukopenia, rash, etc. These drugs should be used under the guidance of a doctor, and those who are allergic to sulfonamides are prohibited from using salbutamol. 3, glucocorticoids: glucocorticoids as a class of drugs for the treatment of AS have strong anti-inflammatory and analgesic effects, but because they cannot control the development of AS and have more side effects, they should not be used as the drug of choice for the treatment of AS. It can be appropriately applied to AS patients with the following conditions (1) For those who cannot tolerate or have poor efficacy of NSAIDs, small dose prednisone treatment can be used instead. The dose is usually not more than 10mg/day. (2) If there is peripheral single joint inflammation such as knee osteoarthritis, glucocorticoids can be used for local injection. (3) Those with severe extra-articular manifestations such as acute iridocyclitis, cardiopulmonary involvement, etc. 4, biological agents: biological agents as a new therapeutic drug for the treatment of AS in recent years, after years of clinical practice confirmed that it is the best and most rapid drug for the treatment of AS at home and abroad, and can significantly improve the lesions visible in the sacroiliac joint or magnetic resonance (MR) of the spine after 2 to 4 weeks of treatment, which is a blessing for AS patients. The main adverse effects are infections and local reactions to injections, the chance of which is not very high, but screening for tuberculosis and hepatitis must be done before using the drug. The disadvantage is that it is expensive and not covered by medical insurance, which puts financial pressure on patients with financial difficulties and those who need to use it for a long time. Overall, as long as AS patients are diagnosed early and treated promptly and reasonably, only a minority of patients will develop severe spinal deformities, and most patients can maintain a normal work and life.