In the 1970s, surgical treatment was popular for a while. However, it was soon discovered that the recurrence rate was as high as 50% after the lesion was removed, and the psychological burden caused by postoperative scar contracture, coupled with the low cancer rate of the disease, led to the gradual abandonment of surgery, unless surgery was considered for those with cancerous or precancerous lesions. Topical medications need to be adhered to for a long time, and will recur once they are discontinued. In addition, topical medications cannot restore the color and elasticity of the skin to normal. Physical therapy such as laser, Bohm light, microwave and other local irradiation therapies have been introduced one after another, but the course of treatment is long and requires several courses of treatment, which brings a lot of inconvenience to patients. Therefore, the disease has long been a difficult problem for patients and gynecologists. Patients with whitening of the vulvar skin are usually not aware of it themselves because they do not feel it, but are discovered by their doctors; in some cases, it is discovered at the time of consultation because of itchy vulva. If the skin of vulva turns white, whether itchy or not, you should go to the hospital for examination. Anyone whose skin is thickened, rough, elevated, ulcerated, ruptured or hardened should be more alert and undergo surgery if necessary. The development of vulvar leukoplakia is slow, and in the past, it was thought that the chance of cancer was mostly removed by surgery, and the emergence of focused ultrasound technology has solved this problem. Because of the good tissue penetration and energy deposition of Hefei knife ultrasound, after the interaction between ultrasound and biological tissue, it can produce biological effects such as thermal effect, cavitation effect and mechanical effect on biological tissue, thus promoting capillary proliferation and improving Blood circulation and skin nutrition, restore the normal tissue structure, promote the regeneration of pigment cells and secretion function, and finally achieve the purpose of complete cure, and not easy to relapse.