In medical science, it is found that if a grandparent has esophageal cancer, the offspring will have a higher probability of developing esophageal cancer than others, which is called genetic susceptibility in medical science. If the father has esophageal cancer, the child will have a higher probability of developing esophageal cancer. The paternal line is higher than the maternal line, and the maternal line is higher than the collateral line. Besides, the occurrence of esophageal cancer is not only related to genetic factors, but also related to dietary factors of patients. For example, eating too much hot and hard food, or eating pickled food, as well as aflatoxin-rich moldy food, can lead to esophageal cancer. In addition, geographically, such as in Henan and Hebei counties, people in this area are more likely to suffer from esophageal cancer than other places due to the lack of trace elements in the local soil. Therefore, besides diet and geographical factors, esophageal cancer has some relationship with genetic factors. Relatively speaking, if the father has esophageal cancer, the children are more likely to have esophageal cancer in the future.