Depression can be relapsed. However, when symptoms reappear soon after a period of remission from medication, it is possible that the disease may “reignite” because the treatment is not complete, which is different from relapse. It is inappropriate for some patients to stop medication in a hurry after a period of improvement because they are worried about the side effects of medication. In general, it seems that the side effects of medication for depression are not as big as patients think. After a relapse of depression, sometimes the effectiveness of the original medication may be reduced, so nowadays, it is generally required to take the medication for depression for a long enough period of time and to reduce the medication slowly before stopping it. If the original effective medication does not work well after a relapse, it is necessary to switch to another medication, which may cause some trouble, but most patients can still achieve better results in the end.