Most headaches in children in the middle of the night are caused by infectious diseases, such as viral and bacterial infections, which cause headaches due to increased body temperature. Bacteria and viruses secrete toxins that have a definite stimulating effect on the fascia of the head and can easily lead to headaches.1 The process of fever can lead to dilation of blood vessels in the head and face, which can also cause headache symptoms, accompanied by muscle aches, coughing, sneezing, and runny nose. If it is a central nervous system infection, headache symptoms are also likely to occur, but the headache is very severe and will be accompanied by nausea, vomiting, mental atrophy, and even high fever convulsions and seizures. 2. Children with headache in the middle of the night should also consider the possibility of primary headache, such as migraine.