There is no uniform understanding of the age of onset of menopause in men. Some scholars project that menopause occurs in men between the ages of 45 and 60 years based on the time of the onset of menopause in women. Some scholars believe that male menopause occurs between the ages of 40 and 65. The mechanism of male menopause syndrome is still unclear, but most scholars believe that the mechanism of menopause in men and women is similar. In men, it is mainly due to the atrophy of the testes, the decrease of testosterone secretion, the feedback stimulation of the pituitary gland secretion function, and the decrease of the response of the atrophied testes to gonadotropin, which causes the imbalance of the sex hormone regulation function in the body. Therefore, some researchers advocate the use of androgen replacement therapy, which can significantly relieve symptoms, but long-term use can prompt prostate hyperplasia and hypertrophy and accelerate the degeneration of testicular function; it has also been reported that it can increase the incidence of prostate cancer. In conclusion, the prevention and treatment of male menopause needs to be further explored. Male menopause syndrome refers to the symptoms of irritability, hypersensitivity, headache and insomnia, and loss of libido in some men during the transition from middle age to old age. Modern medical research has found that men also have menopause, which usually occurs between the ages of 48 and 60. Male menopause syndrome is caused by degenerative changes in the gonads, causing androgens such as testosterone to decrease with age, resulting in a series of physiopathological changes. The degree of this change varies from person to person, with some not feeling it at all, while others exhibit a series of symptoms characterized by disturbances in the vegetative nervous system due to imbalances in the body’s regulation and poor adaptability and a decrease in androgens.