There are many oral medications used in the treatment of ankylosing spondylitis, such as salbutamol, methotrexate, leflunomide, herbal decoction, Chinese medicine, etc. Doctors choose not to use the medication regimen according to different conditions and different patients, because of individual differences, a certain program is not effective does not mean that all programs are not effective, which is one of the reasons for the temporary ineffectiveness of drug therapy, so you need to give time to the doctor to constantly adjust the program to find the best solution for your condition. In addition, these drugs are generally slow to take effect, mostly after 1 month, some even about 2 months, so patients also need to have patience, temporarily ineffective, because the drug has not yet taken effect, which is the second “ineffective” reason There is another reason is that the disease is very stubborn, conventional oral drugs really This is the second “ineffective” reason. Even so, not one biologic can treat all cases of ankylosing spondylitis, and some patients do well with one biologic and not with another.