Kawasaki disease (KD), also known as mucocutaneouslymphnodesyndrome (MCLS), is a systemic vascular inflammatory disease with small and medium-sized arteritis as the main pathological changes, mainly manifested by fever, rash, conjunctival congestion and non-purulent enlargement of cervical lymph nodes. If left untreated, about 20% of children will develop coronary artery injury, which causes coronary artery dilation and coronary artery aneurysm formation, and is the most common cause of acquired heart disease, which is more common in infants and children, mostly within 5 years of age, and more in boys than girls. The etiology of this disease is still unclear, and it is speculated that it may be related to infections, including rickettsia, staphylococcus, streptococcus, retrovirus, and mycoplasma. For pathogenesis, factors such as hyperimmunity, superantigens or heat shock proteins are considered to be involved. Pathologically, the main manifestation is the inflammatory changes of vasculitis, with lesions often involving the coronary arteries, most commonly coronary artery dilation or coronary artery aneurysms. Typical clinical manifestations of Kawasaki disease are more obvious, commonly persistent fever for 7 to 14 days or longer (2 weeks to 1 month), temperature of 39°C or more, may be flaccid fever or retention fever, and characterized by ineffective antibiotic treatment; polymorphic red maculopapular or urticaria-like rash is seen on the trunk, and the palms and plantars may be red and hard and swollen at the fingertips during the acute phase, while typical membranous desquamation appears during the recovery phase; conjunctival congestion appears in both eyes, but The eyes show conjunctival congestion without purulent discharge, the oral mucosa is diffusely congested, the lips are flushed and chapped, and a prune tongue is seen; the lymph nodes in both necks are non-purulent and enlarged; when there is cardiac involvement, corresponding clinical manifestations may occur. Blood tests include elevated white blood cells, anemia, thrombocytosis, CRP, elevated sedimentation, abnormal cardiac enzymes, electrocardiographic changes, and coronary artery lesions on cardiac ultrasound. Treatment of Kawasaki disease includes the application of immunoglobulin, aspirin anti-inflammatory and anti-platelet aggregation and anticoagulation therapy.