What is drug-induced liver damage? Drug-induced liver injury (DILI) is liver damage caused by drugs and their metabolites. The mechanism of its occurrence includes direct toxicity of drugs or their metabolites to the liver, or liver disease caused by the body’s immune response to drugs or their metabolites. Among western pharmaceutical preparations, antibacterial drugs (especially anti-tuberculosis drugs), antipyretic and analgesic drugs, anti-metabolic and antineoplastic drugs, and anti-psychotic drugs cause most of the liver damage. It is worth noting that the rate of liver damage caused by traditional Chinese medicine is increasing year by year. Single herbal medicines such as Lei Gong Tang, Huang Diao, He Shou Wu, Cang Er Zi, Bai Guo, Scutellaria Baicalensis, etc., as well as traditional Chinese medicines such as Strong Bone and Joint Pills, Anti-Eating Pills, Easy Pills, Anti-Eating Tablets, Anti-Cough and Asthma, Hua Tuo Zai Zai Wan, Da Huo Luo Dan Xiao Chai Hu Tang, etc. have been reported to cause drug-related liver damage. Especially for those homemade herbal medicines that do not even have a prescription, even if drug-related liver damage occurs, there is no way to find out which one of the drugs is responsible for it. Therefore, patients need to be cautious in their treatment. How to diagnose drug-induced liver damage? Drug-induced liver damage is called drug-related liver damage or drug-related hepatitis, which mainly has the following characteristics: 1, there is a history of drug use: should occur before the occurrence of liver damage. 50%-70% of the onset within 2 weeks of drug use; 80%-90% of the onset within 8 weeks. 2, most of them have allergic signs: often fever, rash, eosinophilia in the blood (> 6%). 3.The same attack may occur when the same drug is used again. 4.Liver function injury can be hepatocellular, stasis and mixed type. The hepatocellular type is predominantly hepatic parenchymal damage and resembles acute viral hepatitis; the biliary type resembles extrahepatic biliary obstruction and often presents with jaundice, light-colored stools and hepatomegaly. Pruritus is a more specific symptom of bile stasis. The mixed type has characteristics of both. More importantly, liver damage caused by hepatitis B, C, A and E, as well as alcoholic hepatitis, fatty liver, autoimmune disorders and inborn metabolic disorders need to be completely excluded. Currently, drug-related liver damage is taken very seriously both at home and abroad, and different scoring criteria are used for diagnosis. Sometimes a liver biopsy is needed to evaluate the patient for a definitive diagnosis. Every patient suffering from various diseases must get into the habit of keeping the instructions for their medications, and if they are taking herbal tonics, they must also leave their prescriptions in case they need them.