Xiao Zheng is a young man working outside, 26 years old, six months ago because of the left ankle joint swelling pain, can not walk, in a hospital in Jiangmen, check the X-ray shows that the left heel bone suggests bone spur formation, after surgery to remove, the symptoms not only did not improve, 2 months later the left knee joint swelling pain, the nature of the same as before, walking inconvenience, outside the private clinic, after taking painkillers, the symptoms can be reduced, but after stopping the drug, the symptoms recur After taking painkillers, the symptoms were relieved, but after stopping the medication, the symptoms recurred, and the condition became more and more serious, so that he needed to use crutches or other people’s support to walk, making life extremely inconvenient. Later, he returned to his hometown and went to Puning People’s Hospital, where he was seen by Dr. Zhuang Mingcheng, the chief expert in rheumatism of Puning People’s Hospital. After detailed medical history, the patient had a history of low back pain for 5 years, and the pain was aggravated by fixing a certain posture for a longer period of time. In recent years, the pain was reduced, but he felt inflexible when bending over and gradually felt some hunchback. After the relevant examination, Zheng was diagnosed with ankylosing spondylitis, after the correct treatment, Zheng’s knee and ankle swelling and pain have disappeared, crutches are not used, and the back pain at night has also improved. In life, when some teenagers complain to their families about “back pain”, they often get the answer: “Children have no back, that will be back pain, sleep overnight and it will be fine”. The fact that there is a disease called ankylosing spondylitis, which occurs in adolescents, should not be ignored. The incidence of ankylosing spondylitis is a common disease in rheumatology, the incidence in China is about 0.3%, the incidence seems to be higher in the Chaoshan area, the disease has a certain family genetic tendency, more men than women. Commonly seen in adolescents aged 15-30 years old, early manifestation is pain in the lower back and neck, obvious at night or in the morning, relieved after activity, not relieved by rest, accompanied by morning stiffness, some can appear hip, knee and ankle swelling and pain, red eyes, heel pain, weakness, anemia, etc.. As the disease progresses, the range of motion of the spine may be limited to varying degrees, or even completely ankylosed, and after 40-50 years of age, most patients develop a “duck walk” and varying degrees of hunching, and the neck cannot be rotated. Because of the slow progression of the disease, the lumbar pain is intermittent at the beginning and develops persistently only after a few months or years, so early ankylosing spondylitis patients are often overlooked or misdiagnosed as lumbar disc herniation, sciatica, lumbar spondylolisthesis, lumbar strain, etc. Here we remind you that this type of disease is mostly seen in middle-aged and elderly people, when teenagers have back and leg pain, beware of ankylosing spondylitis, and go to a regular hospital rheumatology department in a timely manner. Of course, ankylosing spondylitis is not an incurable disease, let alone a “cancer that won’t die”. As long as early diagnosis and targeted treatment can prevent disability from occurring. The treatment of ankylosing spondylitis includes both medication and rehabilitation exercises. NSAIDs are one of the main drugs used to treat ankylosing spondylitis, suppressing inflammation and reducing joint pain, swelling and morning stiffness. Long-term continuous treatment with NSAIDs can slow down the development of hunchback in patients with ankylosing spondylitis compared to treatment with NSAIDs when necessary. So do not simply assume that NSAIDs are just a painkiller with anti-inflammatory effects. Of course this class of drugs has adverse effects such as gastrointestinal damage, and some appropriate prevention and treatment should be done. Biologics are another new class of drugs that have been clinically proven to be effective in preventing and treating ankylosing spondylitis, such as Ixipro and Classic, but are expensive, limiting their widespread use. Drug therapy is best accompanied by appropriate rehabilitation exercises to maximize prevention of spinal deformities. Rehabilitation exercises include maintaining the mobility of the thorax, maintaining the flexibility of the spine, and maintaining the motor function of the limbs. Patients can often do some deep breathing, chest expansion and rotation, bending knees, hip flexion and head turning exercises; sleep at night to keep lying down, the pillow as low as possible or even go to the pillow lying flat; summer can participate in swimming, especially backstroke is the best therapy. In addition, patients should also maintain optimism, eliminate tension, anxiety, depression and fear, quit smoking and alcohol, regular rest and other psychological treatment means are also effective ways to relieve symptoms. Pay attention to adolescent low back pain, early diagnosis and treatment of ankylosing spondylitis, effective prevention of spinal deformities, and improve the quality of life.