The typical symptom is pain in the right upper abdomen, which can be vague or severe, accompanied by fever, nausea, vomiting, abdominal distension and other related symptoms. Some of the sediment-like gallbladder stones may go downstream and enter the common bile duct, which may cause cholangitis and pancreatitis. For mud-like gallbladder stones with symptoms, it is necessary to perform further relevant examinations, especially NMRCT, liver function, blood and urine, amylase, and routine blood tests, to further determine whether there is a combination of cholecystitis, cholangitis, pancreatitis, etc., and to give timely symptomatic treatment. In case of mud-like gallbladder stones causing symptoms, surgery should be considered to remove the diseased gallbladder.