1.What is the effect of strong column itself on fertility? In fact, regardless of men and women, strong column itself does not have a significant impact on fertility and newborns, nor does it increase complications during pregnancy, such as spontaneous abortion, preterm birth, stalled labor and the occurrence of pre-eclampsia. In women, vaginal delivery is often obstructed by pelvic joint involvement and pain, and cesarean delivery is indicated if the sacroiliac joint is strong. However, due to the slow progression of the lesion, most pregnant women have passed the childbearing stage before the lesion develops to an advanced stage. 2.What is the effect of the drugs used to treat strong column on fertility? At present, the main drugs used in the treatment of strong column are: anti-inflammatory and analgesic non-steroidal anti-inflammatory drugs, such as anti-inflammatory pain, Fotarim, Asimethicin, Meloxicam, Lapsone, Ciloxibol, etc.; basic drugs such as lorazepam and common slow-acting drugs such as Leflunomide, Paeoniflorin, Thalidomide, etc.; and the latest clinical biologics such as Ixepro and Classic. These drugs have a definite effect on men mainly is salazosulfapyridine, which needs to be discontinued 4-6 months before childbirth. Other drugs have little effect and may not be harmful if stopped for 1-2 months before childbirth. Because the pregnancy process is mainly completed by the woman, the effect of drugs on pregnancy is mainly in the woman. Please refer to the previous journal: the application of anti-rheumatic drugs in pregnancy and lactation 3. How to cope with the fertility of male patients? As soon as the spouse becomes pregnant, the effect of the disease and its drugs on fertility in men is over. Therefore, patients with salazosulfapyridine can stop this drug for 4-6 months and other drugs for 1-2 months. 4.How can women cope with childbirth? Before the pregnancy need to be based on the different medications, planned in advance arrangements to stop the drug. It is best to deal with each under the guidance of a doctor according to the specific situation. The above is for patients’ reference only. When ankylosing patients face fertility problems, it is best to deal with them under the guidance of your doctor.