Ankylosing spondylitis is a chronic disease that passes benignly and generally has no involvement of important organs, so it generally does not affect life expectancy. As long as treatment is carried out under the guidance of a rheumatologist, symptoms can be reduced or controlled, complications can be prevented, and physical fitness and health can be maximized. There is no cure for this disease. However, by taking non-steroidal anti-inflammatory drugs can reduce pain, improve sleep and fatigue and other uncomfortable symptoms, and by taking slow-acting anti-rheumatic drugs that change the course of the disease can bring relief or slow down the progress of the disease. With appropriate functional exercise, patients in the early stages can recover well and continue to go to school or return to work; patients in the late stages can also minimize the occurrence of spinal deformities. Therefore, patients with ankylosing spondylitis should actively receive treatment and adhere to appropriate functional exercises on the basis of medication. In this way, the patient’s joints can remain in good functional condition and the majority of patients can live as normal. Ankylosing spondylitis affects each person differently. It is characterized by alternating spontaneous remissions and exacerbations, especially in the early stages of the disease. The prognosis is generally good because the lesions are often relatively mild or self-limiting, most patients are able to work and study full time, and survival is not different from that of the general population, while a minority of patients may exhibit persistent disease activity and develop severe disability early in life. A poor prognosis is often suggested by the following factors: male age of onset ≤16 years; hip involvement; markedly elevated serum immunoglobulin IgA; failure to control pain symptoms after 2 weeks of heavy NSAID therapy; combination of extra-articular symptoms such as cardiovascular involvement, renal amyloidosis, spinal fractures and other serious complications. Hip joint involvement and complete ankylosis of the cervical spine are important causes of functional impairment. In recent years, hip arthroplasty has improved the partial or total loss of function in these patients. In addition, early diagnosis and treatment of the disease can improve the prognosis, and early treatment can delay and postpone the development of the disease and greatly reduce the occurrence of spinal ankylosis, so patients with ankylosing spondylitis should pay sufficient attention to the disease, be confident, and actively cooperate with their doctors.