The symptoms of ABO hemolytic disease mainly include jaundice, anemia and hepatosplenomegaly. The severity of the symptoms depends on the amount of antibodies, the maturity of the newborn and the compensatory hematopoietic capacity, etc. The specific manifestations are as follows: 1. Jaundice: neonatal jaundice appears relatively early, mostly within 24-48 hours after birth, with obvious skin yellowing and rapid aggravation. Children with severe jaundice may also have refusal to eat, poor response, screaming, corns, convulsions and other manifestations of nuclear jaundice; 2, anemia: after the appearance and subsidence of jaundice in newborns, there may be varying degrees of anemia, mainly due to the destruction of a large number of red blood cells when hemolysis occurs. As long as the hematocrit is below 145g/L in the neonatal period, it can be considered as anemia; 3. Hepatosplenomegaly: the bone marrow and extramedullary hematopoietic tissues show compensatory hyperplasia, so it can cause different degrees of hepatosplenomegaly, and microscopic examination can scatter extramedullary hematopoietic foci in the liver, spleen, lung, pancreas, kidney and other tissues.