Hypersplenism is a syndrome of splenomegaly and hemocytopenia caused by a variety of different diseases. The clinical manifestations are splenomegaly and one or more types of hematocrit reduction. It is a common complication of liver cirrhosis. Depending on the disease, different doses of embolic agents are selected. By puncturing the vessel, placing a catheter in the splenic artery and pushing an embolic agent to embolize part of the splenic parenchyma, the treatment of hypersplenism, reducing portal vein pressure, reducing the risk of upper gastrointestinal bleeding and improving liver function is achieved with mild adverse effects. This treatment is preferable to surgical resection, also known as “internal splenectomy”. The advantages include less trauma, partial preservation of organ function, and high safety.