Fantasies of loss of time and space sensation are mostly seen in cases of opioid intoxication. Such drugs include opioids, morphine, cocaine, compound camphor tincture and poppy base, with morphine as the representative (opioids contain 10% morphine). Morphine is mostly metabolized in the liver and excreted via the kidneys within 24 hours, with only trace amounts in the urine after 48 hours. The effect of morphine on the central nervous system is first excitation, then inhibition, mainly inhibition, first inhibit the higher centers of the cerebral cortex, then affect the delayed brain, inhibit the respiratory center and excite the euphoric chemoreceptor area. What are the diagnostic tests for fantasy loss of time and space sensation? Intoxication caused by drug doses exceeding extreme amounts. Drug poisoning can be caused by misuse or overdose as well as drug abuse. Common poisoning-causing drugs include western medicine, Chinese medicine and pesticides. The examination and diagnosis of drug poisoning, the questioning of medical history and clinical examination are basically the same as those of general diseases, but the differential diagnosis of drug poisoning is more complicated. First of all, it should be distinguished whether the patient’s toxic symptoms are due to the development of the disease or caused by the use of drugs, such as headache, dizziness, nausea, vomiting and so on. In case of sudden onset of rash, it should be considered to be related to drugs or toxicity. Doctors should especially ask about the history of medication taking, the variety, dose and time of medication, and also be familiar with the adverse effects of each drug and understand the patient’s family history of drug toxicity reactions. The incubation period of poisoning symptoms is of great reference for diagnosis, mostly 1 to 2 days, up to 10 to 12 days.