Syphilitic alopecia is the skin mucosal damage of stage II syphilis, where the patient suffers from insufficient blood flow to the hair area due to the invasion of the hair follicles by the syphilis spirochete. For syphilitic alopecia, separate treatment is not required, and regular antibiotic treatment for syphilis is sufficient. It is recommended that patients use long-acting penicillin, benzathine penicillin is the more commonly used drugs in the clinic, patients can apply 2.4 million units of benzathine penicillin for intramuscular injection, once a week, three times for a course of treatment. Patients need to adhere to the application of antibiotic treatment until their titers can be controlled at about 1:4, before they can stop the observation, patients need to experience a relatively long clinical titers observation period.