The presence of irritability during menopause can be treated with medications or psychological relief, and can be treated with herbal medicine. The main drugs include tranquilizers and sleeping pills to reduce the sensitivity of peripheral nerves in the body, relieve the symptoms of mood irritability, avoid hot flashes and night sweats, improve the speed of falling asleep and the quality of sleep, and improve the quality of life. The use of traditional Chinese medicine for adjustment, such as sour date soup and tianwang tianxin dan, improves the symptoms of menopausal heartburn with relatively few side effects and requires long-term persistence to improve the effect. If there is a change in mental status, timely psychological counseling to avoid depression and mania, and adjustment through exercise, which can also improve mental status.