Menopausal depression, a common psychosomatic disorder that occurs during menopause. Due to the decrease of estrogen secretion during menopause, a series of psychological symptoms will appear clinically, such as irritability, agitation, insomnia, etc. Physiologically, due to the change of various functions, loss of appetite, dry mouth, palpitations, change of blood pressure, chest tightness, numbness of limbs, loss of libido, etc. The physiological changes aggravate the patient’s psychological discomfort, and often the psychological symptoms will be aggravated with the aggravation of the physiological symptoms, and after treatment After treatment, the physiological symptoms will disappear before the psychological symptoms. The psychological changes of menopausal depression may have serious consequences for the patient and the family if the patient is depressed for a long time. Menopausal depression often manifests itself as disassociation, preference for solitude, low mood, lack of motivation, loss of interest in life and work, and even weeping, sadness and joy, and finally patients feel self-induced pain and even suicidal tendencies. Menopausal depression is not an incurable disease, the treatment of menopausal depression mainly includes psychotherapy and medication. Medication is mainly antidepressant medication and estrogen replacement therapy. Family members should pay attention to understand the patient, care and help the patient to recover as soon as possible, do a good job of psychological care, timely detection and adjustment of the patient’s bad mood. Patients themselves should learn to self-regulate, not to take the bull by the horns, often participate in outdoor activities and communicate more with family and friends to avoid extreme consequences.