Irritability and irritability during menopause can be seen in patients with menopausal syndrome or depression. If irritability and irritability are diagnosed as a result of menopausal syndrome, hormone replacement therapy, such as estrogen, estradiol, estradiol valerate or progesterone, and a combination of estrogen, progesterone and androgen, can be used clinically to improve ovarian function and improve the patient’s mood, thereby improving irritability and irritability. If depression is diagnosed as the cause of irritability, systematic antidepressant treatment is available in clinical practice. Such as the application of antidepressant drugs such as paroxetine, sertraline, venlafaxine and duloxetine. By improving the symptoms associated with depression and thus adjusting the irritability and irritability, it plays an effective therapeutic role.