Gallbladder cancer occurs in women over 60 years old, especially when gallbladder stones are larger than 2.5cm, and repeated frictional stimulation of stones on gallbladder wall can induce gallbladder cancer; 2. Calcification of gallbladder wall, which is the result of porcelain gallbladder, and long-term inflammation of gallbladder wall; 3. Abnormal pancreaticobiliary duct cohesion (APBDJ) is also a predisposing factor for biliary tract tumors, especially gallbladder cancer; 4. 4, pre-cancerous lesions of the gallbladder, such as gallbladder polyps and adenomyosis with a diameter greater than 1.0 cm; 5, atrophic cholecystitis. The diagnosis of gallbladder cancer currently lacks specific tumor markers and mainly relies on imaging diagnosis. With the wide application of ultrasound, CT and MRI in recent years, the diagnosis rate of gallbladder cancer has been improved, but the early diagnosis rate is still low. To improve the early diagnosis rate of gallbladder cancer, the first step is to improve the diagnosis level of primary hospitals, because most of these patients had been examined in primary hospitals first. The busy working conditions of outpatient clinics and the lack of vigilance of examiners in gallbladder cancer diagnosis may lead to missed diagnosis. Therefore, strengthening the education on the vigilance of gallbladder cancer diagnosis is an important way to improve the early diagnosis of gallbladder cancer. At present, there is no very effective means to cure gallbladder cancer, but as long as we pay attention to the susceptibility factors and common symptoms of gallbladder cancer, we can achieve early detection, early diagnosis and early treatment of gallbladder cancer to the maximum extent with the current medical level. In clinical practice, there are some patients who underwent cholecystectomy for gallstones and polyps, but the pathology unexpectedly found gallbladder cancer, which we usually call “accidental gallbladder cancer”. For those early gallbladder cancers that are confined to the mucosa and muscle layer, they can survive for a long time without the need of expanding surgery again. Therefore, early detection of gallbladder cancer and timely management are crucial to the prognosis of gallbladder cancer.