Lactic acidosis is a relatively uncommon but serious complication in diabetic patients, and when it occurs, the morbidity and mortality rate is high, often up to 50% or more. The diagnostic criteria for lactic acidosis, i.e. lactic acid value >2mmol/L detected in human blood and blood pH <7.35. Lactic acid is an intermediate product of glucose metabolism. The breakdown of glucose is divided into aerobic oxidation and anaerobic enzymes. Aerobic oxidation means that it is the main pathway for the breakdown of sugar in the body to produce energy. Glucose is broken down into lactate under anaerobic conditions, which is not the main pathway for energy production but has important pathological and physiological significance. Under normal conditions, most of the pyruvate produced by glycolysis is oxidized in the tricarboxylic acid cycle in fat, muscle, brain and other tissues, while a small proportion is catalyzed by pyruvate carboxylase (PC) to enter the glycogen conduction via oxaloacetate and re-glucose production in the liver and kidney. When PDH is inhibited and NAD is insufficient in diabetes and starvation, the reduction of pyruvate to lactate increases, and ATP is insufficient and pyruvate carboxylase (PC) is restricted, so glycogen isogenesis is also reduced, and pyruvate is converted to lactate, resulting in a sharp increase in blood lactate concentration.