In life, people often find that some women may become eccentric and irritable after reaching the age of 40, and love to argue with others, etc. In fact, this is only part of the emotional changes during menopause. In fact, this is only part of the emotional changes during menopause. Different menopausal women, or even the same person, may have very different conditions at different times. They may show emotional instability, uncontrollable crying, feelings of grief, pessimism about the future, loss of interest in everything, difficulty concentrating, lack of motivation, diminished capacity, emotional anxiety, irritability, insomnia, weakness, increased or lack of appetite, and in some severe cases, even suicidal thoughts or tendencies. The medical term for this condition is perimenopausal depression (which used to be called menopausal depression). Menopausal depression is somewhat insidious, but it can be very harmful, directly affecting the quality of life and even causing serious consequences. Worldwide, the incidence of depression in women is two to three times higher than that in men, and menopause is a period of high depression prevalence. In China, the prevalence of menopausal depression is 30% to 46%, although most patients are mild. The causes of menopausal depression are complex. First, it is related to the neuroendocrine changes in women, and the decline of ovarian function is an important factor. Second, for most women, entering perimenopause (i.e., menopause) is a psychological stimulus in itself, and they may think they are old and useless. Some women face retirement and have difficulty adjusting to the change in role from being a staff member in an office to a woman in a family. With a corresponding reduction in social activities, they may feel abandoned by society. Coupled with the fact that children also grow up and leave the family, they are prone to sullenness and lack of interest in daily life. In addition, women may experience hot flashes, sweating, dizziness, memory loss, decreased work efficiency, and sleep disturbances during the perimenopausal period due to a significant decrease in estrogen levels. If family members do not understand, are indifferent to, or even often blame them, it is more likely to trigger mood disorders and lead to menopausal depression.