Although there is no name for depression in Chinese medicine, people in ancient times realized that poor emotional health could be harmful to human health as early as the Spring and Autumn Period and the Warring States Period, and the concept of “yu” was first introduced into medicine in the Yellow Emperor’s Classic of Internal Medicine. During a long period of time in ancient times, Chinese medicine has built up a complete system of the five main organs from words to terminology, from theory to practice. Depression can be summarized as “depression without relief is a disease of liver and wood” and affects the heart, spleen, kidneys and other organs. Excessive emotional changes can lead to Qi rebellion, emotional disorders, Qi stagnation, phlegm and stasis. In the long run, it damages the body’s qi, blood, yin and yang, causing the brain to lose its nourishment, and the spirit to lose its hiding place, so that the disease changes from real to deficient, or both real and deficient. Some patients also show biphasic symptoms of mania and depression, which are caused by the stagnation of phlegm and qi, and the heat and fire, which can damage the body’s yin and fluids over time. To summarize, depression is caused by the disorder of emotion and will, so that the mood is suppressed for a long time, causing the disorder of qi, and the brain is not controlled, resulting in the disease, on the basis of which also affects the heart, liver, spleen and kidney organs. The main pathological changes are qi disorders, resulting in qi stagnation, phlegm and stasis, disturbing the brain and the mind, and the brain is out of control, or the disease is prolonged and the qi and blood essence cannot be honored in the brain, and the brain is out of control, resulting in depressed mood and other emotional symptoms and reduced ability; the seven emotions are out of control, resulting in the five organs qi disorders, phlegm and stasis blocking the meridians, and various physical symptoms.