An increase in transaminases to 100 U/L has multiple etiologies and can return to normal after 2 weeks with aggressive treatment or removal of the etiology. The normal reference value for aminotransferase is 40 U/L. If aminotransferase rises to 100 U/L, it indicates damage to liver cells for a variety of reasons, which may be drug-related liver injury, alcoholic liver injury or various types of hepatitis. If it is drug-related liver injury or alcoholic liver injury, stop taking or change to other drugs, prohibit drinking alcohol, and at the same time carry out liver-protective treatment, usually 2 weeks after the physical examination, the transaminases can return to normal. If it is caused by hepatitis, the type of hepatitis needs to be clarified, and then anti-inflammatory or antiviral treatment, after active control, it can gradually return to normal, but some patients with chronic hepatitis can take a relatively long time to recover. In addition, in normal people, strenuous exercise, exertion or eating too greasy food can also lead to a transient increase in transaminases, which is not a cause for concern and can usually be recovered after rest and a light diet.