Syphilis blood test results usually include two items, namely the non-syphilis spirochete antibody test and the specific syphilis spirochete antibody test. Due to the different methods used, the non-syphilis spirochete antibody test is often expressed as RPR or USR, and the specific syphilis spirochete antibody test is often expressed as TPPA or TPHA. The clinical significance of the two tests differs. The non-syphilis spirochete antibody test usually shows a positive result 5-6 weeks after syphilis spirochete infection, while all patients with stage II syphilis show a strong positive result. The results of the non-syphilis spirochete antibody test are expressed in terms of dilution, e.g., in stage I syphilis infection, the titer can be as low as 1:2; in stage II syphilis it is higher, up to 1:8 to 1:256 or higher. After proper treatment of syphilis, the titer of the non-syphilis spirochete antibody test correlates with the activity of the disease and can therefore be used to determine the efficacy of syphilis treatment and plays a role in the screening and treatment evaluation of syphilis. When the titer of the non-syphilis spirochete antibody test is low, (less than 1:8), the possibility of a false positive test result should also be considered, and the diagnosis of syphilis should be made by combining the specific syphilis spirochete antibody test with clinical manifestations and medical history. The specific syphilis spirochete antibody test, also known as the syphilis definitive test, is primarily meant to identify cases that are not positive for the syphilis spirochete antibody test. The test has a high specificity and false positives are rare. However, the test usually remains positive for the rest of the patient’s life, so it is of little significance in determining the efficacy of syphilis treatment. Treatment of syphilis should be done at a hospital’s dermatology department under the guidance of a doctor. Also, the syphilis serologic test should be repeated every three months for one year after treatment and every six months for the next two years.