Thalamic injury is a major cause of chronic coma. Recent studies have found that the thalamus is a key node in the brain network and is important for maintaining consciousness. Deep brain stimulation DBS for the treatment of vegetative state is mostly based on this theory. However, it is not clear which nuclei and parts of the thalamus are specifically damaged in patients with vegetative state. After systematic study of brain network changes in patients with chronic coma and correlation analysis with clinical features. For the first time, it was found that the functional connectivity of the central thalamic nuclei to the brain network was significantly weaker in patients with a vegetative state compared to normal subjects. This finding contributes to a better understanding of the pathological mechanisms of chronic coma and provides a favorable basis for the selection of therapeutic targets for neuromodulation therapy to restore the brain network that maintains consciousness.