Ultra-early treatment of coma in hypoxic encephalopathy I have been studying the treatment of ischemic-hypoxic encephalopathy after coma to promote wakefulness. After 10 years of arduous journey, I really appreciate why foreign countries, such as the United States and Canada, designate patients with ischemic-hypoxic encephalopathy coma as vegetative state within one month. After years of clinical work, I really found that the treatment of ischemic-hypoxic encephalopathy is quite difficult, and the main reason why it is so difficult is that the answer cannot be found in the determination of the cause of the disease. In January this year, I suddenly received a call from the director of the intensive care unit of a city people’s hospital in Shanxi, saying that a 44-year-old woman had been resuscitated from cardiac arrest and was on a ventilator, and she was in a coma. I asked Director Wang to do a lumbar puncture immediately, and I wanted to know the brain pressure. Time is life for a comatose patient that’s what I always decided. The next day I flew to the city and saw this patient with a cerebral pressure of 230 mmH20. the day before. At that time, my first feeling was that I was fighting to save this patient. Under my guidance, the patient was given a subarachnoid placement tube of my own invention, which is different from the traditional placement tube. The main point of my invention is that the placement tube can control the level of cerebral pressure, not continuously lower the cerebral pressure, and reduce the appearance of cerebral herniation in the patient. The tube was buried. After 12 days, the patient was taken off the ventilator with a cerebral pressure of 130 mmH20 and transferred to my ward in Beijing, where we did cerebral pressure tests three times and the cerebral pressure fluctuated between 180 and 230 mmH20. The distance between the transverse diameter of the third ventricle in patients with ischemic-hypoxic encephalopathy and traumatic brain coma was measured separately, and it was found that the transverse diameter of the third ventricle in patients with ischemic-hypoxic encephalopathy was 10 mm at one month and 13.6 mm at three months, while the data of 13.6 mm in patients with traumatic brain coma appeared only at 6-9 months. It indicates that the enlarged ventricle and brain atrophy in ischemic-hypoxic encephalopathy coma for 1 month is comparable to the change of ventricle and brain atrophy in traumatic brain coma for 3 months. From this, we found why the vegetative state of patients with ischemic-hypoxic encephalopathy coma was set at one month abroad, and also indicated that such patients are the heaviest type of coma, and appreciated that such patients repeatedly do not wake up in treatment some hospitals cannot continue in carrying out coma promotion. According to the problems found, this time we made a daring attempt on ischemic-hypoxic encephalopathy here, and during one month, we gave him a deep electrical stimulation (DBS) press, the operation lasted 12 hours and was done very successfully. Microelectrode measurement, we asked the neurophysiology unit of the PLA 301 Hospital and experts from the Chinese Academy of Sciences to assist in this surgery. Today is the 8th day after the operation, the second day after the DBS was turned on, I inadvertently gave the patient water and the patient drank in three mouthfuls of water by himself. I saw hope and validation of our judgment that early treatment is unparalleled for patients in coma with ischemic-hypoxic encephalopathy. And missing the time of treatment is a fact that no famous doctor can do anything about.