If Rh haemolytic disease is diagnosed, blood exchange should be given promptly. The disease mostly appears rapidly within 24 hours after birth with yellow skin staining, progresses rapidly and is severe, and blood exchange should be given promptly after diagnosis. Otherwise, bilirubin can directly damage the brain tissue and cause kernicterus, leading to mental retardation or even life-threatening later. The current blood exchange treatment method is very safe and mature, and parents need not worry excessively. This method is a common treatment for jaundice in neonatal units, and there are no serious sequelae after blood exchange treatment, so parents can rest assured that their babies are generally in good condition.