Common symptoms of prostate disease are urinary abnormalities such as frequent and urgent urination and localized pain and discomfort in the lower abdomen and perineum. Rectal palpation plays an important role in the diagnosis and treatment of prostate diseases, and almost all patients with prostate diseases who visit the doctor will receive rectal palpation. However, acute prostatitis and prostate tuberculosis are not suitable for diagnosis and should be taken seriously by doctors and patients. In acute prostatitis, because of the acute inflammatory period, the prostate tissue is congested and edema is obvious, squeezing the prostate fluid will cause tissue damage, and the spread of inflammation can cause bacteria to enter the blood circulation to cause sepsis, and can also cause epididymitis. What are the clues to remind doctors and patients to be cautious in performing rectal palpation? Firstly, it can be combined with the medical history, whether the onset of the disease before the onset of whether it has suffered from systemic infection foci, such as whether there is a septic infection of the skin, or upper respiratory tract infections, or a history of acute urethritis, as well as whether there is a history of urethral instrumentation. Secondly, combined with the symptoms: acute prostatitis acute onset, systemic symptoms of high fever, chills, anorexia, fatigue, etc., local symptoms of urinary frequency, urinary urgency, urinary pain and rectal irritation. Finally, it can be combined with laboratory tests: blood leukocytes are usually 15,000 to 20,000/cubic millimeter, with obvious nuclear left shift. Urine microscopy can see a large number of leukocytes and pus cells, urine pH>7. Urine three-cup test the first cup has debris and pus urine; the second cup is often clearer; the third cup is turbid, with debris and epithelial cells. Urethral secretion examination and bacterial culture can find pathogenic bacteria. Early prostate tuberculosis is often asymptomatic, sometimes the symptoms of chronic prostatitis, manifested as perineal discomfort and falling sensation, lower back pain, anal and testicular pain, pain during bowel movement, pain radiating to the hips, the symptoms gradually aggravated, only from the symptoms, it is very likely to carry out a rectal diagnosis, prostate tuberculosis, if you carry out a rectal diagnosis is also the risk of hematogenous spread. The following characteristics of prostate tuberculosis can be used to guide clinical caution in performing rectal palpation. First, whether there is a history of genitourinary tuberculosis, especially epididymal tuberculosis. Prostate tuberculosis is secondary tuberculosis, male reproductive system tuberculosis rarely occurs in one organ, prostate tuberculosis is not isolated, but occurs simultaneously in the prostate, seminal vesicle glands, vas deferens, epididymis and testes, because epididymal tuberculosis often has clinical manifestations, so it is easy to be detected early by the patient or the doctor, so when suffering from epididymal tuberculosis, we have to be cautious. Secondly, the culture of Mycobacterium tuberculosis in prostate fluid and semen. The examination of looking for tubercle bacilli and antacid bacilli in prostate fluid and semen has great significance for clinical diagnosis although the chance of positive is relatively small.