Whether in academic activities, or in general, every time someone asks me, why do internists or neurologists like to use Dexedrine and you psychiatrists often do not like to use this drug? Personally, I think that no matter what drug can cure the disease and benefit the patient, there is no harm in using it; as they say, practice is the standard for testing the truth. The effect time is faster than the general 5-HT reuptake inhibitors, usually 2-3 days to take effect, a week after the effect is more obvious, the special thing about this drug is that it is a compound, that is, a compound of trifloxystrobin (haloperidol) and tetramethyl anthranilamide (melitrexin). Trifluthione is an antipsychotic that selectively inhibits presynaptic DA receptors at low doses and blocks D2 receptors at certain doses to exert antipsychotic effects. Tetramethylphenidate is a tricyclic antidepressant, which inhibits the reabsorption of 5-HT and NE and increases the synaptic gap content. On the other hand, tetramethylphenidate can counteract the extrapyramidal response produced by trifluthione, and the two drugs antagonize each other, making the anticholinergic effect of this drug weaker than that of tetramethylphenidate alone. Therefore, the clinical aspect of Dextran shows a synergistic effect of the two ingredients in treatment; it can both increase the content of various neurotransmitters such as DA, NE and 5-HT in the synaptic gap in the brain, thus regulating the function of the central nervous system, and make the adverse effects antagonistic to each other, offsetting the adverse effects. This drug is not used in large quantities, and has certain sedative, anxiolytic and antidepressant effects, but the sedative effect is not as good as benzodiazepines, and the antidepressant effect is not as good as commonly used antidepressants; because depressed patients are often accompanied by anxiety symptoms, the use of this drug can quickly eliminate the patient’s anxiety, and it is no wonder that it is a reason for its rapid onset. In the internal medicine and neurology department, most of the patients with symptoms are not too heavy, so the use of this drug is just right, the efficacy is fast; eliminate the symptoms and no effort, no wonder everyone loves it. Dextran is not as some experts say “no benzodiazepine dependence and abuse of adverse reactions” I found from the clinic, the use of this drug is not easy to withdraw, often need a long time to use the drug, so there is still dependence. In the opinion of psychiatrists, Dextran seems to be a bit inappropriate, because it is both an antipsychotic and an antidepressant together, and its pharmacological effects are complicated, so it is often not entered in general drug books and drug manuals; most of the depressed and anxious patients who come to psychiatry are more symptomatic than those who go to other departments, so psychiatrists do not value this drug, especially in psychiatric inpatients. The chances of using this drug are even lower among psychiatric inpatients. In fact, in the process of treating depression and anxiety, antidepressants and certain antipsychotics are used together, not necessarily only with SSRIS drugs. This is an inexpensive and effective treatment. Because the dose of medication is not large, the side effects are relatively small, and I think it is comparable to Dextran in terms of therapeutic effect, but the price is much lower than that of Dextran, and there are at least a few hundred cases of effective treatment by me with this method. In this long treatment process, there are still some things worth remembering, the key is still in the antidepressant with sulpiride as an antipsychotic issue, there are various people who are critical of the addition of sulpiride, some even said to patients that I should not use this drug, regardless of the pharmacological writings clearly written in a small dose of sulpiride has antidepressant effect, even the patient’s self-report also proved that there is indeed efficacy, many patients said to me Many patients said to me: “This medicine you prescribed is the one that can cure me, I don’t believe them!” Practice is persuasive, accusations are useful? The old saying is good, “You’ll never know what you’ve learned on paper, you’ll never know what you’ve done”!