Gallbladder cancer is a malignant tumor with a very high level of nausea. In clinical practice, we encountered some gallbladder cancer cases who often came to the hospital for pain, significant wasting or jaundice. Some patients came to the hospital and were examined to be inoperable due to the occurrence of liver and lung metastases. Some patients underwent surgery and the survival time of the patients was still very unsatisfactory, most of them only survived for about one year despite the great surgery, including liver lobectomy, lymphatic dissection and even adding pancreatic head resection. However, patients have a strong desire to live and often come to you for “consultation”, while doctors can do nothing about it. Looking at these gallbladder cancer patients’ eyes of help, desire, fear and helplessness, my heart is full of sympathy and even self-blame. We can only say some words of comfort and encouragement to the patients, but at the same time inform the families of the serious results of the disease development. At present, there is no cure for the treatment of progressive gallbladder cancer at home and abroad. Early detection and prevention of occurrence remain important initiatives. Here, some knowledge about the prevention of occurrence of gallbladder cancer is disseminated in the hope that people will have better understanding of this disease. Factors related to the occurrence of gallbladder cancer and prevention 1. Gallbladder stones. Clinically, more than 80% of gallbladder cancer patients are combined with gallbladder stones. We found that many patients, especially elderly women, who had gallbladder stones for decades without symptoms or with only mild indigestion, suddenly developed abdominal pain or yellow staining of skin and sclera and dark yellow urine, and were found to have gallbladder cancer during surgery or reported as gallbladder cancer by pathology after surgery (not all patients with these symptoms are gallbladder cancer). It is recommended to remove the gallbladder for large gallbladder stones such as those with a diameter of “3cm” and gallbladder-filled stones. 2. Porcelain gallbladder. We once encountered a patient with calcification of the entire gallbladder wall, which is like a very hard eggshell, and it is obvious on X-ray, so it is recommended to remove it. 3. Atrophic gallbladder. Especially those with combined gallbladder stones have high risk of carcinogenesis and are recommended to be removed. 4.Chronic cholecystitis without stones. Although there are no stones in this type of cholecystitis, it is recommended to remove it if there are frequent symptoms, especially thickening of the gallbladder wall. We also encountered some patients with gallbladder cancer without stones in our clinic, some of them were reported as early stage tumor after surgical resection, and some were progressive gallbladder cancer. 5.Gallbladder polyp-like lesions. Most of the small polyps do not need treatment if they have no symptoms. If the polyps are larger than 1 cm in diameter, it is recommended to remove them. We have encountered some patients with large polyps who underwent laparoscopic cholecystectomy in clinical practice, and the rapid pathology during surgery or postoperative pathological examination was gallbladder cancer. Therefore, resection is recommended for polyps larger than 1 cm in diameter. 6.In addition, for adults over 40 years old, if they can do gallbladder ultrasound every year to know whether there are stones in gallbladder and the thickness of gallbladder wall, etc. is also a strategy for prevention and early detection of lesions.