Kawasaki disease, also known as cutaneous mucosal lymph node syndrome, is an acute febrile disease characterized by skin and mucosal rash, lymph node enlargement and polyarteritis. Most children are between the ages of 2 months and 5 years, but there are also adult patients with a male to female ratio of 1.3 to 1.5:1 and a recurrence rate of 2% to 3%. The etiology of the disease has not been completely elucidated, but genetic susceptibility and infection may be the cause of the disease. Based on the clinical manifestations and excluding other diseases, the diagnosis can be established by having 5 of the following 6 items: (1) persistent fever for more than 5 days. (The fever may last from 2 weeks to 1 month, and the temperature often reaches 39°C.) (2) Bilateral congestion of the conjunctiva. (3) Polymorphic erythema. (Mostly in the trunk) (4) Redness of the lips and mouth Strawberry-like tongue; diffuse congestion of the mucous membranes of the mouth and pharynx. (5) Congestion and hard nodular edema of palms and soles in the acute phase. The fingertips begin to peel during the recovery period (appearing at the skin junction of the nail bed). (6) Acute nonsuppurative cervical lymphomegaly. In most cases the disease is self-limiting. During the acute febrile period, aspirin 30-150 mg/kg can be used, divided into 3-4 oral doses; adjust the dose according to the blood concentration 20-30 mg/dl. After the febrile period, the dose can be reduced by 3-10mg/kg once a day; aspirin can slow down the occurrence of coronary aneurysm and prevent thrombosis. Electrocardiogram and 2D echocardiography should be performed frequently during treatment, and coronary angiography may be done if necessary. The duration of aspirin therapy depends on the clinical course of the disease and is usually given for several months; if a coronary aneurysm occurs, treatment should be continued until the coronary aneurysm resolves. The majority of children have a good prognosis, with a self-limiting course and gradual recovery with appropriate treatment.