Hidden pain in the liver area is not necessarily liver cancer, biliary system diseases as well as some gastrointestinal diseases can cause hidden pain in the liver area. The hepatic region refers to the right upper abdomen of the human body behind the ribs, and the internal organs located in this area include the biliary system, the distal stomach, the duodenum, and the hepatic flexure of the colon, in addition to the liver. Therefore, the causes of right upper abdominal pain include liver diseases, biliary system diseases, certain gastrointestinal diseases, the more common biliary system diseases are gallstones, gallbladder polyps, biliary roundworms; gastrointestinal diseases are duodenal ulcer, chronic gastritis and so on. Besides organic diseases, some functional diseases can also cause vague pain in liver area. Diagnosis of liver cancer mainly relies on imaging examinations, such as ultrasound, CT, nuclear magnetic resonance imaging (NMR). Liver cancer diagnosed due to pain in the liver area is usually in the middle or late stage of liver cancer. For people with high incidence of liver cancer, such as those with chronic hepatitis virus infection and long-term alcohol consumption, it is recommended to have regular physical examination rather than confirming the diagnosis of liver cancer through clinical symptoms.