In recent years, many parents rush to bring their children to the hospital to say that the child high fever 4-5 days, the drip still continues not to subside, eyes red and swollen, mouth and lips chapped, crying, tea and food, what is going on? Dr. Li Yan, chief physician of the Third Affiliated Hospital of Zhengzhou University Heart Center, said such children should be alert to the possibility of Kawasaki disease. She said that Kawasaki disease, also known as cutaneous mucosal lymph node syndrome, was first reported by Dr. Tomisaku Kawasaki in Japan in 1967 and named the disease after him. The disease can develop in infants and children, but 80-85% of patients within 5 years of age, preferably in infants aged 6 to 18 months, more boys, male: female 1.3 to 1.5:1, no obvious seasonality, the incidence of Asian people is higher. In recent years, the incidence of Kawasaki disease in China is gradually increasing trend, its etiology is unknown, mostly manifested as unexplained fever, lasting 5 days or more, antibiotic treatment is ineffective; bilateral conjunctival congestion; oral and pharyngeal mucous membrane diffuse congestion, red lips and dry crack, and a prune tongue; early onset of hand and foot hard swelling and palm and plantar redness, as well as recovery period finger and toe end of the membrane peeling; trunk cadre polymorphous erythema; cervical lymph nodes of non- The swelling of the cervical lymph nodes is non-suppurative, with a diameter of 1.5 cm or larger. Coronary artery damage occurs in about 15-20% of children with this disease, and in severe cases, coronary aneurysms may occur, leading to myocardial infarction and aneurysm rupture. A small number of children with severe coronary aneurysms can be prolonged for several years, leaving behind coronary stenosis, angina pectoris, cardiac insufficiency, ischemic heart disease, and can be life-threatening due to myocardial infarction. Kawasaki disease may also be complicated by gallbladder effusion, arthritis or arthralgia, aseptic encephalomyelitis, facial nerve palsy, hearing loss, acute encephalopathy and neurological changes such as febrile convulsions. The use of antibiotics alone is not effective in the treatment of Kawasaki disease. Intravenous human immunoglobulin, oral aspirin anticoagulation, symptomatic and myocardial nutrition are required in the acute phase. Kawasaki disease is a chronic disease and regular follow-up is recommended after discharge. Children without coronary artery lesions should have a comprehensive examination once in 1, 3, 6 months and 1-2 years after discharge. Children who have developed coronary artery changes are required to have a review of cardiac ultrasound and electrocardiogram once in 1-3 months in addition to the general examination, and every 6 months after the coronary arteries have returned to normal, and after 3 consecutive normal times, the review should be changed to 3-5 years later.