When is biologic therapy suitable for patients with ankylosing spondylitis Biologic agents are an effective drug for the treatment of ankylosing spondylitis, which can quickly and effectively control inflammation and disease activity, relieve pain, and reduce blood sedimentation , CRP and other inflammatory indicators. However, because biologics are prone to relapse after discontinuation, and have the risk of inducing infections and tumors, they are expensive and not reimbursable. Therefore, it is not suitable for every patient with ankylosing spondylitis. Biologics are not suitable for patients with ankylosing spondylitis, as some people say, because the disease will be cured and will be stopped, and the disease will be controlled. What kind of patients are biologics suitable for? (1) Patients who have a clear diagnosis of AS; (2) Patients with early onset of pain at a young age, before 25 years of age; (3) Patients with a clear diagnosis of AS, with severe pain and higher than normal blood sedimentation and C-reactive protein; (4) Patients who have not achieved good results with various oral treatments for AS; (5) Patients with unstable disease and who are planning to have children in the near future; (6) Patients with good financial conditions. (5) Patients with unstable disease who are planning to have children in the near future; (6) Patients with favorable economic conditions. Which patients are not suitable for biologics? 1, the spine has been ankylosed, bone bridges have been formed, and the blood sedimentation, C-reactive protein are normal patients, this situation with biological agents is not meaningful, but increase the risk of infection and tumor. 2, female patients with low back pain over 30 years old, although HLA-B27 positive, sacroiliac joint CT examination can not confirm the diagnosis of ankylosing spondylitis, the use of biological agents should be cautious. 3.Patients with potential risk of tuberculosis, hepatitis and tumor. 4, Patients who are not financially well-off and want to put AS under long-term control are not applicable, and it is better to spend limited financial resources on regular treatment with oral medication.