The full name of ankylosing spondylitis is ankylosing spondylitis, a disease in which inflammation of the sacroiliac joints and spinal attachment points is the main symptom. Ankylosing spondylitis occurs mostly in young and middle-aged men and is characterized by pain, stiffness and functional limitations of the spinal joints, and can be accompanied by multiple lesions in the eyes, lungs and peripheral joints. 1, early symptoms: before the appearance of joint symptoms, many patients can appear weakness, loss of appetite, low fever, wasting and other symptoms, especially in young patients. These symptoms are mostly atypical or mild and can be easily overlooked, thus missing the time for early diagnosis. 2, joint symptoms: patients often feel pain and stiffness in the lower back or lumbosacral area, most obvious in the morning when they get up, many patients can have difficulty sleeping due to pain in the early morning hours, but this pain will be reduced with activity. This is the most typical symptom of ankylosing spondylitis and is mostly the reason why patients visit the clinic. As the disease progresses, the pain in the lower back or lumbosacral area will gradually increase, and the area will expand to the thoracic and cervical spine, up to the entire spinal joint, and gradually appear ankylosing deformities of the spinal joint. 3, extra-articular symptoms: ankylosing spondylitis extra-articular symptoms are complex and diverse, such as cardiac lesions? Aortic valve lesions are more common, the eyes can be seen in conjunctivitis, iritis, uveitis or uveitis, the ears can be seen in chronic otitis media, etc. The symptoms of ankylosing spondylitis are diverse and can be easily overlooked in the early stages. Therefore, young and middle-aged men, once the pain and stiffness in the lower back or lumbosacral area without obvious reasons, need to suspect the possibility of ankylosing spondylitis and should immediately seek medical attention.