Gallbladder stones are a common disease in the digestive system, with a prevalence of about 8-10% in the population, and are more common in women. With the continuous improvement of living standards and the gradual increase in health awareness, gallbladder stones are increasingly found during physical examinations. The causes of gallbladder stones are very complex and have not been completely elucidated yet. The composition and physicochemical properties of bile change, cholesterol becomes supersaturated, and precipitation and crystallization can form stones. Factors such as abnormal quality and quantity of mucin secretion from the gallbladder, reduced contractility of the gallbladder, and stagnation of bile in the gallbladder also contribute to stone formation. Possible associated factors are: race, obesity, high quality diet, female hormones, long-term parenteral nutrition, diabetes, hyperlipidemia, hemolytic anemia, etc. Briefly, the high level of gallbladder stone formation can be summarized as “4F” 1F: female patients 2F: obesity 3F: over 40 years old 4F: multiple pregnancies (pregnancy)