A, ankylosing spondylitis is rheumatic disease 50s, China’s medical profession has called ankylosing spondylitis for rheumatoid spondylitis or central rheumatoid arthritis, in recent years, with the development of medicine, the understanding of the disease continues to deepen, found that the disease and rheumatoid arthritis regardless of the age of onset, gender, the site of prevalence, lesion characteristics and the laboratory tests are not the same. 1, rheumatoid arthritis age peak in 30-50 years old, the proportion of women than men, painful sites in the small joints of the limbs for significant, symmetrical polyarticular lesions, both large and small joints can be involved, the pathology of synovial inflammatory changes, rheumatoid nodules can be seen, rheumatoid factor positive, HLA-B27 negative, no sacroiliac joint and lumbar spine lesions. 2, ankylosing spondylitis, the peak age of predilection is 10-30 years, more men than women, is dominated by chronic progressive inflammation of the sacroiliac and spinal joints, which leads to ossification of the joint ligaments, resulting in bony ankylosis of the patient’s spine and large joints. There is no rheumatoid factor in the serum, while the histocompatibility antigen HLA-B27 is positive in more than 90% of cases. The disease is not limited to the spine, hip, knee, ankle, wrist, shoulder and other large joints of the extremities, but also involves the eyes, heart, lungs, kidneys and many other organs, so ankylosing spondylitis should be a systemic, immune-system-damaging, bone-destroying disease. This shows that ankylosing spondylitis is completely different from rheumatoid arthritis, so in 1963 the International League Against Rheumatism named the disease as ankylosing spondylitis. The first thing you need to do is to get a good idea of what you are getting into. Its early symptoms are pain in the sacroiliac joint, low back, hip or large joints, along with stiffness in the low back, so many people think that ankylosing spondylitis is an orthopedic disease. However, this is not actually the case. Studies have found that the tissues and organs involved in patients with ankylosing spondylitis are systemic, such as the eyes, heart, lungs, kidneys and other multiple organs, HLA-B27 positive up to 90%, some patients with ankylosing spondylitis have elevated immunoglobulins, and the application of immunosuppressive therapy is effective in the clinical treatment of ankylosing spondylitis, all of these facts support that the disease is a systemic, The above facts support that this disease is a systemic, immunologic disease, but its main manifestation is a skeletal lesion. The family heredity of ankylosing spondylitis has long been valued by medical practitioners. In 1973, Brewerton et al. obtained evidence of significant genetic factors in the tissue typing of patients with ankylosing spondylitis, and they found 72 cases of HLA-B27 positivity in 75 typical patients, accounting for 96%, and 31 of their 60 first-degree relatives (51%) had HLA-B27 positivity. 51%) were HLA-B27 positive, whereas in 75 controls, only 3 cases, or 4%, were HLA-B27 positive, suggesting that HLA-B27 positive individuals are closely associated with the development of ankylosing spondylitis. Since the HLA system, like blood group antigens, is genetically determined, heredity is an important cause of the development of ankylosing spondylitis. The incidence of the disease is only about 20% in HLA-B27-positive people, and why the remaining 80% do not suffer from the disease? This suggests that there are other causative factors besides genetic factors. HLA-B27 positivity alone does not necessarily lead to ankylosing spondylitis, and a person with increased body resistance does not necessarily have the disease. In contrast, wind, cold, and dampness can invade the meridians, tendons, and veins, leading to the onset of disease due to the blockage of blood and Qi. Therefore, under the same conditions, a part of HLA-B27-positive people with low resistance to the base body will develop the disease. This disease is a cruel and stubborn disease, relentlessly taking away the youth of countless young adults, but also countless families into a situation of pain and despair, what can be done to save those who are fighting with the disease but can not help the sick body? However, when we open some newspapers and magazines, we find that some medical institutions seem to have overcome this international problem, claiming to be able to completely cure ankylosing spondylitis, but in fact exaggerate the effect of treatment, and even cheat patients out of their money. Here, we can responsibly speak to the majority of patients based on the principle of honesty to patients, so far, there is not a drug or a method in the world that can completely cure strong spondylitis. Five, ankylosing spondylitis is a spinal lesion without systemic treatment Some people say that skeletal lesions are the main manifestation of ankylosing spondylitis, in terms of treatment should be based on the treatment of bone disease. For example, traction can be used to pull apart the gap in the spine to avoid adhesions and fusion, and surgery can be used to correct the curvature and deformation of the spine. However, these are only a symptomatic approach, like adding cold water to boiling water that is being heated, which only temporarily relieves the symptoms and does not address the underlying problem. In addition to the large joints of the extremities, ankylosing spondylitis also involves the eyes, heart, lungs, kidneys and many other organs, and is associated with positive immune tests. Therefore, ankylosing spondylitis is a hereditary immune disease, which is progressive, systemic and other characteristics, rather than a simple orthopedic disease, so the only way to treat it is to carry out systemic treatment in order to “take the bottom out” and restore various immune indicators to normal, so as to truly treat both the symptoms and the root cause. This is the reason why many patients take a lot of painkillers, while the disease instead progresses progressively. So, can patients only suffer from the disease in silence? Of course not, early ankylosing spondylitis, with varying degrees of restriction of spinal activity, blurred and slightly dense sacroiliac joint space, widened joint space, normal vertebral small joints or joint space changes, can be treated to avoid fusion of the spine and joints, while making a variety of laboratory indicators back to normal. Patients with advanced ankylosis are able to achieve clinical remission by treating them so that their pain symptoms disappear, bone destruction stops, and immune function is restored. This recovery process requires a period of immune recovery, resorption of sclerotic bone and bone bridges, bone stabilization, and restoration of joint function.