Ichthyosis is mainly a skin disease, most of which are hereditary factors, and a few are related to kidney disease. Ichthyosis belongs to a group of skin diseases with varying degrees of ichthyosis-like exfoliation accompanied by skin roughness and dryness and keratinization. Most of them are hereditary skin diseases, which may be due to the genetic mutation of one or both parents, or it may be caused by spontaneous mutation of the patient’s genes. In addition, acquired ichthyosis may occur as a result of certain diseases that develop in adulthood, such as renal diseases such as renal failure, which is a metabolic disease and belongs to a reciprocal causal relationship with ichthyosis, as deletion of the gene encoding the steroid sulfate lyase enzyme is associated with X-linked ichthyosis. Therefore, it can be judged that the occurrence of ichthyosis may have a certain relationship with kidney disease, and ichthyosis may also be accompanied by kidney damage. It is recommended to go to the hospital in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy.