Vulvar leukoplakia, officially called vulvar dystrophy or vulvar precancerous lesion, is a disease caused by cellular lesions, due to which the cells are unable to absorb nutrients from the body, resulting in a decrease in the patient’s body resistance and recovery power. As more than 80% of the patients will have different degrees of vulvar skin whitening or whitening. 1.Infection and inflammatory stimulation of the vulva: This is the main cause of vulvar blemish, which accounts for about 50% of the patients. There are many factors that cause vulvar infection and inflammatory stimulation, such as poor hygiene habits, not often using pH4 weak acid formula feminine care solution to clean the vulva, wearing chemical fiber underwear, unclean sanitary products, bathing in the bath, swimming in the bathhouse, etc., resulting in vaginal inflammation, if not treated in time, inflammatory secretion infiltration to the perineum, long-term infection stimulation, will cause damage to the skin and mucous membrane, redness, ulceration and degeneration, which will gradually develop into vulvar leukoplakia. will gradually develop into vulvar leukoplakia. 2.Endocrine disorders: endocrine disorders are caused by pathological perversion of endocrine glands and tissues, or endocrine disorders caused by genetics, enzyme defects and immune function, etc. Through the determination of tritium (h3) labeled thymidine, it is believed that there is a protein hormone in the dermis that can inhibit the growth of epidermal cell division and only act locally on the epidermis with tissue specificity, called inhibin, which makes the local connective tissue proliferation and the stimulation of epidermal metabolism there dysregulate leading to vulvar leukoplakia. 3, genetic factors: about 10-30% of patients with vulvar leukoplakia. It is caused by heredity, and the genetically induced vulvar leukoplakia is mainly of atrophic type, and the patients are mainly young girls. In clinical practice, patients under 15 years old should first pay attention to genetic factors and inquire whether there are patients with vulvar leukoplakia in their parents’ families. 4, other diseases: such as diabetes, vitiligo, vulvar eczema, vulvar itching, etc., such as indiscriminate use of drugs, improper treatment, may also lead to or aggravate the formation and development of leukoplakia. There are various reasons for vulvar leukoplakia, but the main reason is caused by pubic infection and inflammatory stimulation. So women must pay more attention in their daily life to reduce the infection and also the occurrence of positive vaginal inflammation. This requires hygiene, diet and other aspects. In general, vulvar dystrophy can cause local lesions, and according to the difference of its histopathological changes, it is divided into hyperplastic dystrophy, sclerosing mossy dystrophy, and mixed dystrophy.