As early as the 1840s, the Western scholar Werner, through clinical observation, found that men after the age of 50 experienced a decline in physical fitness, easy fatigue, memory loss, inattention, irritability, depression, hot flashes, night sweats and reduced sexual function, and named it menopausal syndrome. It should be clear that the name menopause syndrome in men is not appropriate. In 2002, the International Society for the Study of Older Men named the syndrome late-onset hypotestis (LOH), defining the disorder as an age-related hypotestis that occurs in middle-aged and older men, and was endorsed by the International Society of Gynecology and the European Urological Association. Therefore, the more accurate name for menopausal syndrome in men would be “late-onset hypospadias”. There are many causes of menopausal syndrome in men, but after middle age, the testicular function gradually decreases with age and in the body, necessarily involving various aspects of the extensive physiological role of the testes. The men’s menopause syndrome is summarized in the following aspects of performance: 1, psycho-psychological symptoms: mainly a change in temperament, such as depressed mood, sadness, sullen desire to cry; or nervousness, hypersensitivity, temperamental; or rumination, catching wind, lack of trust, self-confidence, reduced work efficiency. 2.Phytodysfunction: mainly cardiovascular system symptoms, such as palpitations and palpitations, precordial discomfort, or blood pressure fluctuations, dizziness and tinnitus, baking and sweating; gastrointestinal symptoms, such as loss of appetite, bloating, constipation and leakage; neurasthenia, such as insomnia, sleeplessness and dreaminess, easy to wake up, memory loss, forgetfulness, slow reaction, etc. 3, sexual dysfunction: mainly for the loss of sexual desire or even no, impotence, premature ejaculation, weak ejaculation, poor pleasure, reduced semen volume, etc. 4, physical symptoms: such as bone, joint and muscle pain, osteoporosis, back and leg pain, skin atrophy, abdominal obesity, etc. Middle-aged and elderly men with the above symptoms and accompanied by reduced serum testosterone levels, after excluding the effects of other diseases and drugs, suggesting that the symptoms may be related to reduced testosterone levels, experimental testosterone supplementation therapy section to further determine the relationship between symptoms and testosterone levels, only through experimental treatment proved effective, to finalize the diagnosis of LOH. Patients with delayed hypotestosteronism are currently treated by Western medicine mainly through testosterone supplementation with oral testosterone undecanoate pills. It should be highlighted that for LOH western medical supplementation of testosterone may aggravate or cause common prostate diseases in middle and old age, such as prostate enlargement and prostate cancer. Therefore, prostate-specific antigen should be routinely checked prior to treatment and symptoms of lower urinary tract obstruction due to BPH should be evaluated. In addition, testosterone preparations should be contraindicated in patients with severe sleep apnea syndrome, patients with severe heart disease or liver failure, and patients with erythrocytosis.