1.Paraquat is very toxic and can be absorbed through skin, gastrointestinal tract and respiratory tract to cause acute poisoning, mostly caused by oral aqueous solution, it is the herbicide that causes the most acute poisoning and death in human beings. It has multi-system damage to people, especially the most serious damage to the lungs. After absorption, it is mainly accumulated in lungs and absorbed by alveolar type I and type II cells, which are activated into free radicals in cells and cause lung damage. 3. There is no special treatment for paraquat poisoning. The poisoned person should be cleaned and detoxified quickly and thoroughly: (1) vomiting; (2) gastric lavage with 30% white clay, mud water or activated charcoal, which can be taken together with laxatives; (3) blood perfusion as early as possible; (4) medication: high-dose corticosteroid plus cyclophosphamide; antioxidant and free radical scavenger (SOD, VitC), insulin, VitB1, etc.; (5) early paraquat poisoning should be avoided Oxygen should be avoided in the early stage of paraquat poisoning, and high concentration of oxygen should never be used; if there is difficulty in breathing, cyanosis and partial pressure of oxygen is lower than 40mmHg, oxygen inhalation of more than 21% can be used. In conclusion, the first aid treatment of paraquat poisoning is difficult, and there is a lack of rescue methods that can effectively reduce the mortality rate, so we should pay attention to the early diagnosis and treatment of acute paraquat poisoning.