The average age of menopause for Chinese women is 49.5 years old, but with the development of social and economic conditions, women’s health has improved greatly and the age of menopause is being postponed. At this time, there may be typical symptoms of menopause, such as reduced estrogen levels, hot flashes, sweating, excessive dreaming and fatigue. In this case, it is recommended to check sex hormone six to determine whether the ovaries are showing signs of premature ovarian failure, and if there is premature ovarian failure, you can choose estrogen combination or single estrogen for treatment. During the course of treatment, it is important to exclude pathologies such as breast, heart, and lower extremity venous thrombosis.