Ankylosing spondylitis (AS) is a chronic inflammatory disease that mainly affects the sacroiliac joints, spinal prominences, paraspinal soft tissues and peripheral joints, and may be accompanied by extra-articular manifestations. The main clinical manifestations are back, back, neck, hip and hip pain, as well as joint swelling and pain, and in severe cases, spinal deformity and joint ankylosis may occur. Symptoms of the disease The onset of the disease is insidious. Patients gradually develop pain and/or stiffness in the hip and back, especially when lying down for a long time (at night) or sitting for a long time, and have difficulty in turning over, and the stiffness in the back is obvious in the morning or when sitting for a long time, but relieves after activity. Some patients feel severe pain in the hip and hip area, which occasionally radiates to the periphery. In the early stage of the disease, the pain is mostly intermittent on one side, and after a few months, the pain is mostly persistent bilaterally. As the disease progresses from the sacroiliac joint to the lumbar spine, thoracic and cervical spine, pain, restricted movement or spinal deformity will occur in the corresponding areas. It has been reported that about 45% of our patients start with peripheral arthritis. The disease often affects young adults, and patients are often at an important stage of study and work. If they are not treated properly, it can cause a decrease in their ability to study and work, or even disability, which can have a greater impact on the patient. The severity of the disease varies greatly in clinical terms. In some patients, the disease continues to progress repeatedly, and within one to two years, significant spinal ankylosis and hunchback deformation can appear, and some patients with severe hip joint involvement can become bedridden for a long time. However, the prognosis is poor for patients with young age of onset, early hip involvement, recurrent iridocyclitis and secondary amyloidosis, delayed diagnosis, untimely and unreasonable treatment, and those who do not adhere to long-term functional exercise. Prevention and treatment principles: 1, the correct understanding of ankylosing spondylitis, biological agents are the treatment of ankylosing spondylitis inflammatory lesions of special drugs, not only anti-inflammatory and analgesic, but also can effectively stop the development of the disease, the earlier the use of the more beneficial. 2, bone neonatal is another pathological damage of ankylosing spondylitis, TNF-a antagonists are known to inhibit Dickkopf-1, thus promoting bone neonatal, should be used at the right time to inhibit bone neonatal drugs. 3, the disappearance of joint pain is not the same as the disease has been controlled, long-term continuous treatment is required. 4, how to choose the right medication, it is best to find rheumatologists guidance.